Estimating the total number of protein folds
نویسندگان
چکیده
منابع مشابه
Estimating the total number of protein folds.
Many seemingly unrelated protein families share common folds. Theoretical models based on structure designability have suggested that a few folds should be very common while many others have low probability. In agreement with the predictions of these models, we show that the distribution of observed protein families over different folds can be modeled with a highly-stretched exponential. Our re...
متن کاملEstimating the number of protein folds.
A number of fundamental questions in structural biology concern the diversity of protein architectures (or folds). Here, we address two of them, the size of the universe of folds, and the distribution of sequence families among them, using an analysis based on a new and rigorous statistical sampling method. In particular we show that the number of known non-transmembrane protein folds is approx...
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Using the data on proteins encoded in complete genomes, combined with a rigorous theory of the sampling process, we estimate the total number of protein folds and families, as well as the number of folds and families in each genome. The total number of folds in globular, water- soluble proteins is estimated at about 1000, with structural information currently available for about one-third of th...
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Proteins employ a wide variety of folds to perform their biological functions. How are these folds first acquired? An important step toward answering this is to obtain an estimate of the overall prevalence of sequences adopting functional folds. Since tertiary structure is needed for a typical enzyme active site to form, one way to obtain this estimate is to measure the prevalence of sequences ...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 1999
ISSN: 0887-3585,1097-0134
DOI: 10.1002/(sici)1097-0134(19990601)35:4<408::aid-prot4>3.0.co;2-a